In this Course we will deal with simple and complex abdominal wall defects, speak about congenital malformations of the spine and the face go beyond the typical neural tube defect and cleft, explore the association of congenital heart defects and brain development, and the potential tools, question the management options for conditions such as congenital diaphragmatic hernia and fetal hydrops and we challenge the current practice on genetic investigation and pathological analysis upon the diagnosis of syndromic conditions.